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For individuals with seizures: For those who have seizures or a heritage of seizures, tramadol may cause or worsen seizures. Speak with your medical professional about regardless of whether tramadol is Safe and sound for you personally. Under the necessities of the REMS, drug firms with accredite

Diazepam and its metabolites are very bound to plasma proteins (diazepam ninety eight%). Diazepam and its metabolites cross the blood-Mind and placental boundaries and may also be present in breast milk in concentrations about one particular tenth of Those people in maternal plasma (times 3 to 9 sub

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are attempting to become pregnant, are previously pregnant or are breastfeeding - co-codamol will not be ordinarily recommended in pregnancy or whilst breastfeeding Diazepam ne treba davati u ranoj trudno?i, odnosno trudnicama u prvom trimestru trudno?e osim ako to nije krajnje neophodno. Primena